ProfPPIdb: Pairs of physical protein-protein interactions predicted for entire proteomes.

ABSTRACT:

Motivation

Protein-protein interactions (PPIs) play a key role in many cellular processes. Most annotations of PPIs mix experimental and computational data. The mix optimizes coverage, but obfuscates the annotation origin. Some resources excel at focusing on reliable experimental data. Here, we focused on new pairs of interacting proteins for several model organisms based solely on sequence-based prediction methods.

Results

We extracted reliable experimental data about which proteins interact (binary) for eight diverse model organisms from public databases, namely from Escherichia coli, Schizosaccharomyces pombe, Plasmodium falciparum, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, and for the previously used Homo sapi

SUBMITTER: Tran L 

PROVIDER: S-EPMC6051629 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature