Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis.

ABSTRACT:

Background

Diabetic ketoacidosis in children may cause brain injuries ranging from mild to severe. Whether intravenous fluids contribute to these injuries has been debated for decades.

Methods

We conducted a 13-center, randomized, controlled trial that examined the effects of the rate of administration and the sodium chloride content of intravenous fluids on neurologic outcomes in children with diabetic ketoacidosis. Children were randomly assigned to one of four treatment groups in a 2-by-2 factorial design (0.9% or 0.45% sodium chloride content and rapid or slow rate of administration). The primary outcome was a decline in mental status (two consecutive Glasgow Coma Scale scores of <14, on a scale ranging from 3 to 15, with lower scores indicating worse mental status) duri

SUBMITTER: Kuppermann N 

PROVIDER: S-EPMC6051773 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature