Anaplastic lymphoma kinase rearrangement in surgically resected stage IA lung adenocarcinoma.

ABSTRACT:

Background

It has not been determined if adjuvant chemotherapy would be helpful for completely resected early-stage lung adenocarcinoma even with unfavorable genetic markers. As the positive anaplastic lymphoma kinase (ALK) rearrangement is associated with aggressive clinical feature in lung adenocarcinoma, we evaluated the treatment outcomes of completely resected stage IA lung adenocarcinoma according to initial ALK status.

Methods

This is a retrospective cohort study including 309 patients with surgically resected stage IA lung adenocarcinoma from February 2010 to December 2013. Patients were screened for ALK rearrangement using immunohistochemistry. A positive ALK status was defined as an immunohistochemistry score of 2+ or more. Both disease-

SUBMITTER: Shin SH 

PROVIDER: S-EPMC6051845 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature