Critical Role for the Microbiota in CX₃CR1⁺ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.

ABSTRACT: The intestinal barrier is vulnerable to damage by microbiota-induced inflammation that is normally restrained through mechanisms promoting homeostasis. Such disruptions contribute to autoimmune and inflammatory diseases including inflammatory bowel disease. We identified a regulatory loop whereby, in the presence of the normal microbiota, intestinal antigen-presenting cells (APCs) expressing the chemokine receptor CX₃CR1 reduced expansion of intestinal microbe-specific T helper 1 (Th1) cells and promoted generation of regulatory T cells responsive to food antigens and the microbiota itself. We identified that disruption of the microbiota resulted in CX₃CR1⁺ APC-dependent inflammatory Th1 cell responses with increased pathology after pathogen infection. Colo

SUBMITTER: Kim M 

PROVIDER: S-EPMC6051886 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature