C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products.

ABSTRACT: Covering: up to the end of 2017 C-C bond formations are frequently the key steps in cofactor and natural product biosynthesis. Historically, C-C bond formations were thought to proceed by two electron mechanisms, represented by Claisen condensation in fatty acids and polyketide biosynthesis. These types of mechanisms require activated substrates to create a nucleophile and an electrophile. More recently, increasing number of C-C bond formations catalyzed by radical SAM enzymes are being identified. These free radical mediated reactions can proceed between almost any sp3 and sp2 carbon centers, allowing introduction of C-C bonds at unconventional positions in metabolites. Therefore, free radical mediated C-C bond formations are frequently found in the construction of structurally unique and

SUBMITTER: Yokoyama K 

PROVIDER: S-EPMC6051890 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature