Increased Single-Fiber Jitter Level Is Associated With Reduction in Motor Function With Aging.

ABSTRACT:

Objective

Age-associated skeletal muscle weakness is a major contributing factor to an increased late life mortality and morbidity, but its neurobiology is poorly understood. Previously, we provided histological evidence of dying-back axonal degeneration of motor neurons and denervation of neuromuscular junctions in age-associated muscle weakness. Given this, we aimed to evaluate the relation between impaired neuromuscular transmission and various aspects of age-associated muscle weakness.

Design

We compared two electrophysiological measures, single-fiber jitter and compound motor action potential in mice of different age groups, and correlated them with various physical performance measures, such as grip strength, standing and walking time, and treadmill performance.

Res

SUBMITTER: Chung T 

PROVIDER: S-EPMC6051904 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature