Sympathetic Neuronal Activation Triggers Myeloid Progenitor Proliferation and Differentiation.

ABSTRACT: There is a growing body of research on the neural control of immunity and inflammation. However, it is not known whether the nervous system can regulate the production of inflammatory myeloid cells from hematopoietic progenitor cells in disease conditions. Myeloid cell numbers in diabetic patients were strongly correlated with plasma concentrations of norepinephrine, suggesting the role of sympathetic neuronal activation in myeloid cell production. The spleens of diabetic patients and mice contained higher numbers of tyrosine hydroxylase (TH)-expressing leukocytes that produced catecholamines. Granulocyte macrophage progenitors (GMPs) expressed the β₂ adrenergic receptor, a target of catecholamines. Ablation of splenic sympathetic neuronal signaling using surgical, chemical, and

SUBMITTER: Vasamsetti SB 

PROVIDER: S-EPMC6051926 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature