Nano-photosensitizer based on layered double hydroxide and isophthalic acid for singlet oxygenation and photodynamic therapy.

ABSTRACT: Singlet oxygen has won a great deal of attention to catalysis and biological studies due to its strong oxidizing properties. However, the photosensitizers which require for the generation of singlet oxygen remain inadequate because of their lack of long-wavelength absorption, weak hydrophilicity, and poor biocompatibility. Here, we develop near-infrared laser activated supramolecular photosensitizers (isophthalic acid/layered double hydroxide nanohybrids) for efficient two-photon photodynamic therapy. The singlet oxygen quantum yield of nanohybrid is up to 0.74. Critically, in vitro tests verify the superior anti-cancer properties of nanohybrid with an IC₅₀ determine to be 0.153 μg mL^-1. The nanohybrids take advantage of the superior tissue penetration of 808 nm laser

SUBMITTER: Gao R 

PROVIDER: S-EPMC6052022 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature