A micron-scale surface topography design reducing cell adhesion to implanted materials.

ABSTRACT: The micron-scale surface topography of implanted materials represents a complementary pathway, independent of the material biochemical properties, regulating the process of biological recognition by cells which mediate the inflammatory response to foreign bodies. Here we explore a rational design of surface modifications in micron range to optimize a topography comprised of a symmetrical array of hexagonal pits interfering with focal adhesion establishment and maturation. When implemented on silicones and hydrogels in vitro, the anti-adhesive topography significantly reduces the adhesion of macrophages and fibroblasts and their activation toward effectors of fibrosis. In addition, long-term interaction of the cells with anti-adhesive topographies markedly hampers cell proliferation, correl

SUBMITTER: Robotti F 

PROVIDER: S-EPMC6052105 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature