Behavioral Context Determines Network State and Variability Dynamics in Monkey Motor Cortex.

ABSTRACT: Variability of spiking activity is ubiquitous throughout the brain but little is known about its contextual dependance. Trial-to-trial spike count variability, estimated by the Fano Factor (FF), and within-trial spike time irregularity, quantified by the coefficient of variation (CV), reflect variability on long and short time scales, respectively. We co-analyzed FF and the local coefficient of variation (CV2) in monkey motor cortex comparing two behavioral contexts, movement preparation (wait) and execution (movement). We find that the FF significantly decreases from wait to movement, while the CV2 increases. The more regular firing (expressed by a low CV2) during wait is related to an increased power of local field potential (LFP) beta oscillations and

SUBMITTER: Riehle A 

PROVIDER: S-EPMC6052126 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature