Periodic Fluctuation of Tidal Volumes Further Improves Variable Ventilation in Experimental Acute Respiratory Distress Syndrome.

ABSTRACT: In experimental acute respiratory distress syndrome (ARDS), random variation of tidal volumes (V_T ) during volume controlled ventilation improves gas exchange and respiratory system mechanics (so-called stochastic resonance hypothesis). It is unknown whether those positive effects may be further enhanced by periodic V_T fluctuation at distinct frequencies, also known as deterministic frequency resonance. We hypothesized that the positive effects of variable ventilation on lung function may be further amplified by periodic V_T fluctuation at specific frequencies. In anesthetized and mechanically ventilated pigs, severe ARDS was induced by saline lung lavage and injurious V_T (double-hit model).

SUBMITTER: Guldner A 

PROVIDER: S-EPMC6052143 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature