Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis.

ABSTRACT: Chronic inflammation is a potential systemic risk factor for many bladder dysfunctions, including interstitial cystitis (IC). However, the underlying mechanism through which a healthy bladder protects itself from inflammatory triggers remains unknown. In this study, we identified odor compounds in urine obtained from IC patients and healthy controls. Using comprehensive solid-phase microextraction-gas chromatography-time-of-flight-mass spectrometry (SPME-GC-TOF-MS) profiling and bioinformatics, we found that levels of urinary volatile metabolites, such as menthol, were significantly reduced in IC patients, compared to healthy controls. In an attempt to understand the mechanistic meaning of our volatile metabolites data and the role of menthol in the immune system, we performed two independ

SUBMITTER: Shahid M 

PROVIDER: S-EPMC6052149 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature