Segmental Additive Tissue Engineering.

ABSTRACT: Segmental bone defects caused by trauma and disease represent a major clinical problem worldwide. Current treatment options are limited and often associated with poor outcomes and severe complications. Bone engineering is a promising alternative solution, but a number of technical challenges must be addressed to allow for effective and reproducible construction of segmental grafts that meet the size and geometrical requirements needed for individual patients and routine clinical applications. It is important to devise engineering strategies and standard operating procedures that make it possible to scale up the size of bone-engineered grafts, minimize process and product variability, and facilitate technology transfer and implementation. To address these issues, we have combined traditiona

SUBMITTER: Sladkova M 

PROVIDER: S-EPMC6052158 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature