Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4⁺ T cell proliferation.

ABSTRACT: Neisseria gonorrhoeae is an exclusive human pathogen that evades the host immune system through multiple mechanisms. We have shown that N. gonorrhoeae suppresses the capacity of antigen-presenting cells to induce CD4⁺ T cell proliferation. In this study, we sought to determine the gonococcal factors involved in this adaptive immune suppression. We show that suppression of the capacity of antigen-pulsed dendritic cells to induce T cell proliferation is recapitulated by administration of a high-molecular-weight fraction of conditioned medium from N. gonorrhoeae cultures, which includes outer membrane vesicles that are shed during growth of the bacteria. N. gonorrhoeae PorB is the most abundant protein in N. gonorrhoeae-derived vesicles, and treat

SUBMITTER: Zhu W 

PROVIDER: S-EPMC6052219 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature