Dysregulation of NAD⁺ Metabolism Induces a Schwann Cell Dedifferentiation Program.

ABSTRACT: The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the importance of SC metabolism in nerve function and in peripheral neuropathies associated with metabolic disorders. Nicotinamide adenine dinucleotide (NAD⁺) is a crucial molecule in the regulation of cellular metabolism and redox homeostasis. Here, we investigated the roles of NAD⁺ metabolism in SC functions in vivo by mutating NAMPT, the rate-limiting enzyme of NAD⁺ biosynthesis, specifically in SCs. NAMPT SC knock-out male and female mice (NAMPT SCKO mice) had delayed SC maturation in development and

SUBMITTER: Sasaki Y 

PROVIDER: S-EPMC6052240 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature