The Importance of Aquaporin 1 in Pancreatitis and Its Relation to the CFTR Cl^- Channel.

ABSTRACT: Aquaporins (AQPs) facilitate the transepithelial water flow involved in epithelial fluid secretion in numerous tissues; however, their function in the pancreas is less characterized. Acute pancreatitis (AP) is a serious disorder in which specific treatment is still not possible. Accumulating evidence indicate that decreased pancreatic ductal fluid secretion plays an essential role in AP; therefore, the aim of this study was to investigate the physiological and pathophysiological role of AQPs in the pancreas. Expression and localization of AQPs were investigated by real-time PCR and immunocytochemistry, whereas osmotic transmembrane water permeability was estimated by the dye dilution technique, in Capan-1 cells. The presence of AQP1 and CFTR in the mice and human pancreas were investigated

SUBMITTER: Venglovecz V 

PROVIDER: S-EPMC6052342 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature