Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging.

ABSTRACT: Inability to preserve proteostasis with age contributes to the gradual loss of function that characterizes old organisms. Defective autophagy, a component of the proteostasis network for delivery and degradation of intracellular materials in lysosomes, has been described in multiple old organisms, while a robust autophagy response has been linked to longevity. The molecular mechanisms responsible for defective autophagic function with age remain, for the most part, poorly characterized. In this work, we have identified differences between young and old cells in the intracellular trafficking of the vesicular compartments that participate in autophagy. Failure to reposition autophagosomes and lysosomes toward the perinuclear region with age reduces the efficiency of their fusion and the subs

SUBMITTER: Bejarano E 

PROVIDER: S-EPMC6052466 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature