Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice.

ABSTRACT: Aging is the largest risk factor for cardiovascular disease, yet the molecular mechanisms underlying vascular aging remain unclear. Mitochondrial DNA (mtDNA) damage is linked to aging, but whether mtDNA damage or mitochondrial dysfunction is present and directly promotes vascular aging is unknown. Furthermore, mechanistic studies in mice are severely hampered by long study times and lack of sensitive, repeatable and reproducible parameters of arterial aging at standardized early time points. We examined the time course of multiple invasive and noninvasive arterial physiological parameters and structural changes of arterial aging in mice, how aging affects vessel mitochondrial function, and the effects of gain or loss of mitochondrial function on vascular aging. Vascular aging was first det

SUBMITTER: Foote K 

PROVIDER: S-EPMC6052475 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature