Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension.

ABSTRACT: DNA methylation increases with age. The objective of this study was to investigate whether compound H, a potential activator of DNA demethylases, attenuates aging-related arterial stiffness and hypertension. Aged mice (24-27 months) and adult mice (12 months) were used. Pulse wave velocity (PWV), a direct measure of arterial stiffness, and blood pressure (BP) were increased significantly in aged mice. Notably, daily treatments with compound H (15 mg/kg, IP) for 2 weeks significantly attenuated the aging-related increases in PWV and BP. Compound H abolished aging-associated downregulation of secreted Klotho (SKL) levels in both kidneys and serum likely by enhancing DNA demethylase activity and decreasing DNA methylation. Aging-related arterial stiffness was associated with accumulation of s

SUBMITTER: Chen K 

PROVIDER: S-EPMC6052484 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature