Nonmuscle myosin II isoforms interact with sodium channel alpha subunits.

ABSTRACT: Sodium channels play pivotal roles in health and diseases due to their ability to control cellular excitability. The pore-forming α-subunits (sodium channel alpha subunits) of the voltage-sensitive channels (i.e., Na_v1.1-1.9) and the nonvoltage-dependent channel (i.e., Na_x) share a common structural motif and selectivity for sodium ions. We hypothesized that the actin-based nonmuscle myosin II motor proteins, nonmuscle myosin heavy chain-IIA/myh9, and nonmuscle myosin heavy chain-IIB/myh10 might interact with sodium channel alpha subunits to play an important role in their transport, trafficking, and/or function. Immunochemical and electrophysiological assays were conducted using rodent nervous (brain and dorsal root ganglia) tissues and ND7/23 cells coexpressing Na

SUBMITTER: Dash B 

PROVIDER: S-EPMC6052497 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature