The epigenetic clock and pubertal, neuroendocrine, psychiatric, and cognitive outcomes in adolescents.

ABSTRACT:

Background

Molecular aging biomarkers, such as epigenetic age predictors, predict risk factors of premature aging, and morbidity/mortality more accurately than chronological age in middle-aged and elderly populations. Yet, it remains elusive if such biomarkers are associated with aging-related outcomes earlier in life when individuals begin to diverge in aging trajectories. We tested if the Horvath epigenetic age predictor is associated with pubertal, neuroendocrine, psychiatric, and cognitive aging-related outcomes in a sample of 239 adolescents, 11.0-13.2 years-old.

Results

Each year increase in epigenetic age acceleration (AA) was associated with 0.06 SD units higher weight-for-age, 0.08 SD units taller height-for-age, -0.09 SD units less missed from the expected adult he

SUBMITTER: Suarez A 

PROVIDER: S-EPMC6052515 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature