Alzheimer disease pathology and the cerebrospinal fluid proteome.

ABSTRACT:

Background

Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegeneration have not yet been fully explored. Using a robust automated MS-based proteomic biomarker discovery workflow, we measured cerebrospinal fluid (CSF) proteomes to explore their association with well-established markers of core AD pathology.

Methods

Cross-sectional analysis was performed on CSF collected from 120 older community-dwelling adults with normal (n = 48) or impaired cognition (n = 72). LC-MS quantified hundreds of proteins in the CSF. CSF concentrations of β-amyloid 1-42 (Aβ_1-42), tau, and tau phosphorylated at thr

SUBMITTER: Dayon L 

PROVIDER: S-EPMC6052524 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature