Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia.

ABSTRACT:

Background

A subset of patients with the nonfluent variant of primary progressive aphasia (PPA) exhibit concomitant single-word comprehension problems, constituting a 'mixed variant' phenotype. This phenotype is rare and currently not fully characterized. The aim of this study was twofold: to assess the prevalence and nature of single-word comprehension problems in the nonfluent variant and to study multimodal imaging characteristics of atrophy, tau, and amyloid burden associated with this mixed phenotype.

Methods

A consecutive memory-clinic recruited series of 20 PPA patients (12 nonfluent, five semantic, and three logopenic variants) were studied on neurolinguistic and neuropsychological domains relative to 64 cognitively intact healthy older control subjects. The neuroima

SUBMITTER: Schaeverbeke J 

PROVIDER: S-EPMC6052568 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature