Concise Review: Rational Use of Mesenchymal Stem Cells in the Treatment of Ischemic Heart Disease.

ABSTRACT: The capacity of stem and progenitor cells to stimulate cardiac regeneration has been studied for almost 20 years, with very promising preclinical data and mixed clinical results. Several cell types have been studied, identified by their cell surface markers, differentiation capacity and their secreted growth factors. Bone marrow derived mesenchymal stem cells (MSCs) have been found to have potent regenerative capacity, through multiple mechanisms, including mesoderm lineage differentiation, immunomodulation, and paracrine stimulation. MSCs also secrete exosomes and microvesicles, which themselves contain potent angiogenic cytokines or mRNA molecules with effects on their local milieu. This concise review summarizes the mechanisms of MSC-based cardiac regeneration and highlighting results f

SUBMITTER: Ward MR 

PROVIDER: S-EPMC6052612 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature