Effects of mesenchymal stromal cells versus serum on tendon healing in a controlled experimental trial in an equine model.

ABSTRACT:

Background

Mesenchymal stromal cells (MSC) have shown promising results in the treatment of tendinopathy in equine medicine, making this therapeutic approach seem favorable for translation to human medicine. Having demonstrated that MSC engraft within the tendon lesions after local injection in an equine model, we hypothesized that they would improve tendon healing superior to serum injection alone.

Methods

Quadrilateral tendon lesions were induced in six horses by mechanical tissue disruption combined with collagenase application 3 weeks before treatment. Adipose-derived MSC suspended in serum or serum alone were then injected intralesionally. Clinical examinations, ultrasound and magnetic resonance imaging were performed over 24 weeks. Tendon biopsies for histological asse

SUBMITTER: Ahrberg AB 

PROVIDER: S-EPMC6052633 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature