Variability analysis and inter-genotype comparison of human respiratory syncytial virus small hydrophobic gene.

ABSTRACT:

Background

Small hydrophobic (SH) gene is one of the mostly diverse genomic regions of human respiratory syncytial virus (HRSV). Its coding region constitutes less than 50% of the complete gene length, enabling SH gene to be highly variable and the SH protein highly conserved. In standard HRSV molecular epidemiology studies, solely sequences of the second hypervariable region of the glycoprotein gene (HVR2) are analyzed. To what extent do the strains identical in HVR2 differ elsewhere in genomes is rarely investigated. Our goal was to investigate whether diversity and inter-genotype differences observed for HVR2 are also present in the SH gene.

Methods

We sequenced 198 clinical samples collected within a limited area and time frame. In this HRSV collection, rapid and signifi

SUBMITTER: Ivancic-Jelecki J 

PROVIDER: S-EPMC6052705 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature