Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM⁺ and Transient IgG⁺ Memory B Cells.

ABSTRACT: Although immune memory often lasts for life, this is not the case for certain vaccines in some individuals. We sought a mechanism for this phenomenon by studying B cell responses to phycoerythrin (PE). PE immunization of mouse strains with Igh^b immunoglobulin (Ig) variable heavy chain (V_H) genes elicited affinity-matured switched Ig memory B cells that declined with time, while the comparable population from an Igh^a strain was numerically stable. Igh^b strains had larger numbers of PE-specific naive B cells and generated smaller germinal center responses and larger numbers of IgM memory cells than the Igh^a strain. The properties of PE-specific B cells in Igh^b mice correlated with usage of a single V_H that afforded

SUBMITTER: Pape KA 

PROVIDER: S-EPMC6052797 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature