Time series clustering of mRNA and lncRNA expression during osteogenic differentiation of periodontal ligament stem cells.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) are regulatory molecules that participate in biological processes such as stem cell differentiation. Periodontal ligament stem cells (PDLSCs) exhibit great potential for the regeneration of periodontal tissue and the formation of new bone. However, although several lncRNAs have been found to be involved in the osteogenic differentiation of PDLSCs, the temporal transcriptomic landscapes of mRNAs and lncRNAs need to be mapped to obtain a complete picture of osteoblast differentiation. In this study, we aimed to characterize the time-course expression patterns of lncRNAs during the osteogenic differentiation of PDLSCs and to identify the lncRNAs that are related to osteoblastic differentiation.

Methods

We cultured PDLSCs in an osteogenic

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC6052852 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature