Decreased Expression of Sulfatase 2 in the Brains of Alzheimer's Disease Patients: Implications for Regulation of Neuronal Cell Signaling.

ABSTRACT:

Background

The human sulfatase 1 (SULF1) and sulfatase 2 (SULF2) genes modulate cell signaling and homeostasis in many tissues. Gene expression analyses have implicated SULF2 in disease pathogenesis, including Alzheimer's disease (AD), but changes in brain SULF2 expression have not been directly established.

Objective

To investigate the expression of SULF1 and SULF2 in brain tissues from AD cases and cognitively normal controls.

Methods

Autopsy tissue from AD cases (n = 20) and age-and gender-matched cognitively normal controls (n = 20) were identified from the Mayo Clinic Alzheimer's Disease Patient Registry neuropathology database. Tissue slides were stained for SULF1 and SULF2 protein expression in the hippocampus and frontal lobe and an expression sc

SUBMITTER: Roberts RO 

PROVIDER: S-EPMC6052874 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature