The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4⁺ Th2 Differentiation.

ABSTRACT: Posttranscriptional gene regulation by RNA-binding proteins, such as HuR (elavl1), fine-tune gene expression in T cells, leading to powerful effects on immune responses. HuR can stabilize target mRNAs and/or promote translation by interacting with their 3' untranslated region adenylate and uridylate-rich elements. It was previously demonstrated that HuR facilitates Th2 cytokine expression by mRNA stabilization. However, its effects upon IL-2 homeostasis and CD4⁺ Th2 differentiation are not as well understood. We found that optimal translation of Il2ra (CD25) required interaction of its mRNA with HuR. Conditional HuR knockout in CD4⁺ T cells resulted in loss of IL-2 homeostasis and defects in JAK-STAT signaling, Th2 differentiation, and cytokine productio

SUBMITTER: Techasintana P 

PROVIDER: S-EPMC6052877 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature