The importance of stool DNA methylation in colorectal cancer diagnosis: A meta-analysis.

ABSTRACT: A large number of tumor-related methylated genes have been suggested to be of diagnostic and prognostic values for CRC when analyzed in patients' stool samples; however, reported sensitivities and specificities have been inconsistent and widely varied. This meta-analysis was conducted to assess the detection accuracy of stool DNA methylation assay in CRC, early stages of CRC (advanced adenoma, non-advanced adenomas) and hyperplastic polyps, separately. We searched MEDLINE, Web of Science, Scopus and Google Scholar databases until May 1, 2016. From 469 publications obtained in the initial literature search, 38 studies were included in the final analysis involving 4867 individuals. The true positive, false positive, true negative and false negative of a stool-based DNA methylation biomarker

SUBMITTER: Mojtabanezhad Shariatpanahi A 

PROVIDER: S-EPMC6053185 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature