Influenza A/H3N2 virus infection in immunocompromised ferrets and emergence of antiviral resistance.

ABSTRACT: Influenza viruses can cause severe life threatening infections in high-risk patients, including young children, the elderly and patients with compromised immunity due to underlying medical conditions or immunosuppressive treatment. The impaired immunity of these patients causes prolonged virus infection and combined with antiviral treatment facilitates the emergence of viruses with resistance mutations. The diverse nature of their immune status makes them a challenging group to study the impact of influenza virus infection and the efficacy of antiviral therapy. Immunocompromised ferrets may represent a suitable animal model to assess influenza virus infection and antiviral treatment strategies in immunocompromised hosts. Here, ferrets were given a daily oral solution of mycophenolate mofet

SUBMITTER: Roosenhoff R 

PROVIDER: S-EPMC6053203 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature