Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen.

ABSTRACT:

Background

Many studies have identified changes in the brain associated with obsessive-compulsive disorder (OCD), but few have examined the relationship between genetic determinants of OCD and brain variation.AimsWe present the first genome-wide investigation of overlapping genetic risk for OCD and genetic influences on subcortical brain structures.

Method

Using single nucleotide polymorphism effect concordance analysis, we measured genetic overlap between the first genome-wide association study (GWAS) of OCD (1465 participants with OCD, 5557 controls) and recent GWASs of eight subcortical brain volumes (13 171 participants).

Results

We found evidence of significant positive concordance between OCD risk variants and variants associated with greater nucleus accumbens a

SUBMITTER: Hibar DP 

PROVIDER: S-EPMC6053271 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature