Adenosine Receptors Influence Hypertension in Dahl Salt-Sensitive Rats: Dependence on Receptor Subtype, Salt Diet, and Sex.

ABSTRACT: The influence of adenosine receptors on blood pressure in salt-sensitive hypertension is unknown. Here, we examined the effects of salt diets on arterial blood pressures (radiotelemetry) in female and male Dahl salt-sensitive wild-type versus female and male Dahl salt-sensitive A₁, A_2A, or A_2B receptor knockouts (A₁KOs, A_2AKOs, and A_2BKOs, respectively). At baseline, all rats were on a 0.3% salt diet; then separate groups were switched to either 4% or 8% salt diet for 2 weeks. Compared with wild-types, baseline pressures were not affected by knockout of A₁ or A_2B receptors; yet, mean, systolic, and diastolic pressures were significantly (P<0.01) higher in A_2AKOs versus wild-types, an e

SUBMITTER: Jackson EK 

PROVIDER: S-EPMC6053282 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature