New Agents, Emerging Late Effects, and the Development of Precision Survivorship.

ABSTRACT: Incremental improvements in the treatment of children and adolescents with cancer have led to 5-year survival rates reaching nearly 85%. In the past decade, impressive progress has been made in understanding the biology of many pediatric cancers. With that understanding, multiple new agents have become available that offer the promise of more-effective and less-toxic treatment. These include agents that target various cell surface antigens and engage the adaptive immune system, as well as those that interfere with key signaling pathways involved in tumor development and growth. For local control, surgery and radiation techniques also have evolved, becoming less invasive or featuring new techniques and particles that more precisely target the tumor and limit the dose to normal tissue. Never

SUBMITTER: Chow EJ 

PROVIDER: S-EPMC6053298 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature