Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell.

ABSTRACT: To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.

SUBMITTER: Montesinos-Rongen M 

PROVIDER: S-EPMC6053313 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature