Altered prefrontal correlates of monetary anticipation and outcome in chronic pain.

ABSTRACT: Chronic pain may alter both affect- and value-related behaviors, which represents a potentially treatable aspect of chronic pain experience. Current understanding of how chronic pain influences the function of brain reward systems, however, is limited. Using a monetary incentive delay task and functional magnetic resonance imaging (fMRI), we measured neural correlates of reward anticipation and outcomes in female participants with the chronic pain condition of fibromyalgia (N = 17) and age-matched, pain-free, female controls (N = 15). We hypothesized that patients would demonstrate lower positive arousal, as well as altered reward anticipation and outcome activity within corticostriatal circuits implicated in reward processing. Patients demonstrated lower arousal ratings as compared with c

SUBMITTER: Martucci KT 

PROVIDER: S-EPMC6053327 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature