Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis.

ABSTRACT:

Background

Inhaled hypertonic saline (HS) has been shown to increase mucociliary clearance (MCC) and improve clinical outcomes in adults and adolescents with cystic fibrosis (CF). However, in younger children with CF, a large study failed to demonstrate clinical benefits. This discrepancy could reflect pharmacodynamic differences in the MCC response to HS in different populations. We previously demonstrated the absence of a sustained effect of HS on MCC in healthy adults and in this study sought to characterize the durability of the MCC response to HS in adults with CF.

Methods

At two study sites, MCC was measured in CF adults using gamma scintigraphy during three separate visits: at baseline, 15 min, and 4 h after a single dose of HS (7% NaCl, 4 mL). Particle clearance rate

SUBMITTER: Trimble AT 

PROVIDER: S-EPMC6053331 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature