FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins.

ABSTRACT: Ferlin proteins participate in such diverse biological events as vesicle fusion in C. elegans, fusion of myoblast membranes to form myotubes, Ca²⁺-sensing during exocytosis in the hair cells of the inner ear, and Ca²⁺-dependent membrane repair in skeletal muscle cells. Ferlins are Ca²⁺-dependent, phospholipid-binding, multi-C2 domain-containing proteins with a single transmembrane helix that spans a vesicle membrane. The overall domain composition of the ferlins resembles the proteins involved in exocytosis; therefore, it is thought that they participate in membrane fusion at some level. But if ferlins do fuse membranes, then they are distinct from other known fusion proteins. Here we show that the central FerA domain from dysferlin, myoferlin, and otoferli

SUBMITTER: Harsini FM 

PROVIDER: S-EPMC6053371 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature