Genetic variants in SEC16B are associated with body composition in black South Africans.

ABSTRACT:

Objective

The latest genome-wide association studies of obesity-related traits have identified several genetic loci contributing to body composition (BC). These findings have not been robustly replicated in African populations, therefore, this study aimed to assess whether European BC-associated gene loci played a similar role in a South African black population.

Methods

A replication and fine-mapping study was performed in participants from the Birth to Twenty cohort (N = 1,926) using the Metabochip. Measurements included body mass index (BMI), waist and hip circumference, waist-to-hip ratio (WHR), total fat mass, total lean mass and percentage fat mass (PFM).

Results

SNPs in several gene loci, including SEC16B (P_adj <  9.48 × 10^-7), NEGR1 (P

SUBMITTER: Sahibdeen V 

PROVIDER: S-EPMC6053407 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature