Lipid profiling of polarized human monocyte-derived macrophages.

ABSTRACT: The highly orchestrated transcriptional and metabolic reprogramming during activation drastically transforms the main functions and physiology of human macrophages across the polarization spectrum. Lipids, for example, can modify protein function by acting remotely as signaling molecules but also locally by altering the physical properties of cellular membranes. These changes play key roles in the functions of highly plastic immune cells due to their involvement in inflammation, immune responses, phagocytosis and wound healing processes. We report an analysis of major membrane lipids of distinct phenotypes of resting (M0), classically activated (M1), alternatively activated (M2a) and deactivated (M2c) human monocyte derived macrophages from different donors. Samples were subjected to super

SUBMITTER: Montenegro-Burke JR 

PROVIDER: S-EPMC6053630 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature