Interleukin-15 facilitates muscle regeneration through modulation of fibro/adipogenic progenitors.

ABSTRACT:

Background

Chronic muscle injury is characteristics of fatty infiltration and fibrosis. Recently, fibro/adipogenic progenitors (FAPs) were found to be indispensable for muscular regeneration while were also responsible for fibrosis and fatty infiltration in muscle injury. Many myokines have been proven to regulate the adipose or cell proliferation. Because the fate of FAPs is largely dependent on microenvironment and the regulation of myokines on FAPs is still unclear. We screened the potential myokines and found Interleukin-15 (IL-15) may regulate the fatty infiltration in muscle injury. In this study, we investigated how IL-15 regulated FAPs in muscle injury and the effect on muscle regeneration.

Methods

Cell proliferation assay, western blots, qRT-PCR, immunohistochemistr

SUBMITTER: Kang X 

PROVIDER: S-EPMC6053744 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature