Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors.

ABSTRACT:

Background

Light exposure induces oxidative stress, which contributes to ocular diseases of aging. Blue light provides a model for light-induced oxidative stress, lipid peroxidation and retinal degeneration in Drosophila melanogaster. In contrast to mature adults, which undergo retinal degeneration when exposed to prolonged blue light, newly-eclosed flies are resistant to blue light-induced retinal degeneration. Here, we sought to characterize the gene expression programs induced by blue light in flies of different ages to identify neuroprotective pathways utilized by photoreceptors to cope with light-induced oxidative stress.

Results

To identify gene expression changes induced by blue light exposure, we profiled the nuclear transcriptome of Drosophila photoreceptors from on

SUBMITTER: Hall H 

PROVIDER: S-EPMC6053765 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature