Antioxidant and Trace Element Supplementation Reduce the Inflammatory Response in Critically Ill Burn Patients.

ABSTRACT: Oxidative stress after burn injury induces inflammatory and hypermetabolic responses associated with adverse outcomes. We propose that antioxidant and trace element supplementation may reduce oxidative stress and subsequently alleviate inflammation and hypermetabolism, thus improving clinical outcomes. We conducted a cohort study of adult patients with an acute burn injury admitted to our provincial burn center. Patients in the antioxidant group received an intravenous infusion of multivitamins and trace elements for the first 14 days after admission. The inflammatory profile was assessed at early time points, < 14 days postburn, and later time points, ≥ 15 days postburn, and included interleukin (IL)-1β, interferon-γ, IL-1 receptor antagonist, IL-6, granulocyte-macrophage colony-stimulati

SUBMITTER: Rehou S 

PROVIDER: S-EPMC6053770 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature