Prometastatic Molecular Profiles in Breast Tumors From Socially Isolated Women.

ABSTRACT:

Background

Social isolation is associated with accelerated breast cancer progression and increased disease recurrence and mortality, but the underlying biological mechanisms remain poorly understood. In preclinical models, beta-adrenergic signaling from fight-or-flight stress responses can stimulate prometastatic processes in the tumor microenvironment including upregulation of M2 macrophages, epithelial-mesenchymal transition (EMT), and lymphovascular invasion. This study examines whether the same pathways are upregulated in breast tumors from socially isolated cancer patients.

Methods

EMT and M1/M2 macrophage gene expression programs were analyzed by genome-wide transcriptional profiling, and lymphatic and vascular density were assessed by immunohistochemistry in primary t

SUBMITTER: Bower JE 

PROVIDER: S-EPMC6054021 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature