In vivo study and thermodynamic investigation of two lanthanum complexes, La(dpp)₃ and La(XT), for the treatment of bone resorption disorders.

ABSTRACT: Bone density diseases such as osteoporosis affect a significant number of people worldwide. Lanthanide ions are functional mimics of calcium ions, able to substitute for Ca²⁺ in the bone mineral component, hydroxyapatite (HAP). Bone undergoes a continuous remodelling cycle and lanthanides can affect this cycle, exerting a positive influence on bone mineral. We have been engaged in efforts to find new lanthanide containing complexes as active agents for treatment of these diseases and have identified two lead compounds, 3-hydroxy-1,2-dimethylpyridin-4(1H)-one (Hdpp) and a phosphinate-EDTA derivative, bis[[bis(carboxymethyl)amino]-methyl]phosphinate (H₅XT). In this paper, we report in vivo data for the first time for the two lead compounds. The pharmacokin

SUBMITTER: Cawthray JF 

PROVIDER: S-EPMC6054118 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature