Maternal diet-induced obesity programmes cardiac dysfunction in male mice independently of post-weaning diet.

ABSTRACT:

Aims

Obesity during pregnancy increases risk of cardiovascular disease (CVD) in the offspring and individuals exposed to over-nutrition during fetal life are likely to be exposed to a calorie-rich environment postnatally. Here, we established the consequences of combined exposure to a maternal and post-weaning obesogenic diet on offspring cardiac structure and function using an established mouse model of maternal diet-induced obesity.

Methods and results

The impact of the maternal and postnatal environment on the offspring metabolic profile, arterial blood pressure, cardiac structure, and function was assessed in 8-week-old C57BL/6 male mice. Measurement of cardiomyocyte cell area, the transcriptional re-activation of cardiac fetal genes as well as genes involved in the regu

SUBMITTER: Loche E 

PROVIDER: S-EPMC6054211 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature