Hydroxyproline Metabolism and Oxalate Synthesis in Primary Hyperoxaluria.

ABSTRACT: Background Endogenous oxalate synthesis contributes to calcium oxalate stone disease and is markedly increased in the inherited primary hyperoxaluria (PH) disorders. The incomplete knowledge regarding oxalate synthesis complicates discovery of new treatments. Hydroxyproline (Hyp) metabolism results in the formation of oxalate and glycolate. However, the relative contribution of Hyp metabolism to endogenous oxalate and glycolate synthesis is not known.Methods To define this contribution, we performed primed, continuous, intravenous infusions of the stable isotope [¹⁵N,¹³C₅]-Hyp in nine healthy subjects and 19 individuals with PH and quantified the levels of urinary ¹³C₂-oxalate and ¹³C₂-glycolate form

SUBMITTER: Fargue S 

PROVIDER: S-EPMC6054332 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature