Cerebellar and prefrontal cortical alterations in PTSD: structural and functional evidence.

ABSTRACT:

Background

Neuroimaging studies have revealed that disturbances in network organization of key brain regions may underlie cognitive and emotional dysfunction in posttraumatic stress disorder (PTSD). Examining both brain structure and function in the same population may further our understanding of network alterations in PTSD.

Methods

We used tensor-based morphometry (TBM) and intrinsic connectivity distribution (ICD) to identify regions of altered volume and functional connectivity in unmedicated individuals with PTSD (n=21) and healthy comparison (HC) participants (n=18). These regions were then used as seeds for follow-up anatomical covariance and functional connectivity analyses.

Results

Smaller volume in the cerebellum and weaker structural covariance between the

SUBMITTER: Holmes SE 

PROVIDER: S-EPMC6054445 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature