Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.

ABSTRACT: The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD mouse population fed chow or high-fat diet and integrated these data with complementary multi-omics datasets. We identified several lipid species and lipid clusters with specific phenotypic and molecular signatures and, in particular, cardiolipin species with signatures of healthy and fatty liver. Genetic analyses revealed quantitative trait loci for 68% of the lipids (lQTL). By multi-layered omics analyses, we show the reliability of lQTLs to uncover candidate genes that can regulate the levels of lipid species. Additionally, we identified lQTLs that mapped to genes ass

SUBMITTER: Jha P 

PROVIDER: S-EPMC6054463 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature